摘要 :
Here we report the examination of two
convenient strategies, the use of a D-amino acid residue or a
glycoside segment, for increasing the proteolytic resistance of
supramolecular hydrogelators based on small peptides. Our
results ...
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Here we report the examination of two
convenient strategies, the use of a D-amino acid residue or a
glycoside segment, for increasing the proteolytic resistance of
supramolecular hydrogelators based on small peptides. Our
results show that the introduction of D-amino acid or glycoside
to the peptides significantly increases the resistance of the
hydrogelators against proteinase K, a powerful endopeptidase.
The insertion of D-amino acid in the peptide backbone,
however, results relatively low storage moduli of the hydrogels,
likely due to the disruption of the superstructures of the
molecular assembly. In contrast, the introduction of a
glycoside to the C-terminal of peptide enhances the
biostability of the hydrogelators without the significant decrease of the storage moduli of the hydrogels. This work suggests
that the inclusion of a simple glycogen in hydrogelators is a useful approach to increase their biostability, and the gained
understanding from the work may ultimately lead to development of hydrogels of functional peptides for biomedical applications
that require long-term biostability.
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